Challenges and opportunities to minimize the dose in the neurovascular bundles during prostate radiotherapy
NVB sparing without compromising target coverage is feasible. No clinically relevant benefit was found for non-coplanar compared to coplanar NVB sparing plans, although overall statistically superior. Further sparing of the NVB comes at the cost of target coverage, for which a Pareto front could be used as a tool in clinical practise.
Authors
- Linda Rossi (ORCID: https://orcid.org/0000-0002-3705-2504)
- Femke E. Froklage
- Alison Tree (ORCID: https://orcid.org/0000-0002-5033-424X)
- Mischa S. Hoogeman (ORCID: https://orcid.org/0000-0002-4264-9903)
- Maaike T.W. Milder (ORCID: https://orcid.org/0009-0003-1200-640X)
- Luca Incrocci (ORCID: https://orcid.org/0000-0001-9994-763X)
- Victor J. Brand (ORCID: https://orcid.org/0000-0001-8115-0227)
Institutions
- Institute of Cancer Research (GB)
- Royal Marsden Hospital (GB)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.ctro.2025.100959
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Royal Marsden NHS Foundation Trust
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care