Antimicrobial <i>p</i> -terphenyl derivatives from the deep-sea cold seep-derived fungus <i>Aspergillus candidus</i>
Four new <i>p</i>-terphenyl derivatives named phenylcandilides C-F, together with nine known analogues, were isolated from the deep-sea cold-seep-derived fungus <i>Aspergillus candidus</i> HNNU0546. Compounds <b>10</b> and <b>12</b> exhibited antibacterial activity against <i>Staphylococcus aureus</i> with MIC values of 21.6 and 23.6 µM, respectively. Compound <b>5</b> showed antifungal activity with an EC<sub>50</sub> value of 3.0 µM against phytopathogenic fungus <i>Alternaria</i> sp., while compound <b>6</b> exhibited inhibitory activity against <i>Curvularia australiensis</i> and <i>Alternaria</i> sp. with the same EC<sub>50</sub> values of 3.0 µM, respectively.
Authors
- Zhuang Han
- Haixin Chen (ORCID: https://orcid.org/0000-0002-3659-3747)
- Guang‐Ying Chen (ORCID: https://orcid.org/0000-0002-6729-0597)
- Xu‐Hua Nong (ORCID: https://orcid.org/0009-0009-5852-4599)
- Qianwa Liang (ORCID: https://orcid.org/0000-0003-1473-9749)
- Jinrui Shi (ORCID: https://orcid.org/0000-0002-0428-6777)
- Yiyi Liu (ORCID: https://orcid.org/0000-0002-2188-6336)
Institutions
- Hainan Normal University (CN)
- Chinese Academy of Sciences (CN)
- Botswana Geoscience Institute (BW)
- Institute of Deep-Sea Science and Engineering (CN)
- BGI Research (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1080/14786419.2025.2487153
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province