Vitamin K preserves gamma‐glutamyl carboxylase activity against carbamylations in uremia: Implications for vascular calcification and adjunct therapies
In conclusion, this study clearly demonstrates that the vitamin K-dependent enzyme GGCX plays a significant role in uremic calcification and may be modulated to help prevent pathological changes.
Authors
- Jürgen Floege (ORCID: https://orcid.org/0000-0002-8763-828X)
- Letícia Prates Roma (ORCID: https://orcid.org/0000-0001-9527-0529)
- Rafael Kramann (ORCID: https://orcid.org/0000-0003-4048-6351)
- Sofía de la Puente-Secades (ORCID: https://orcid.org/0000-0003-3949-1030)
- Nadine Kaesler (ORCID: https://orcid.org/0000-0001-8097-7660)
- Vera Jankowski (ORCID: https://orcid.org/0009-0003-6416-0230)
- Sadasivam Kaushik (ORCID: https://orcid.org/0000-0001-7856-8374)
- Jochen Grommes (ORCID: https://orcid.org/0000-0002-6419-6802)
- Alexander Gombert (ORCID: https://orcid.org/0000-0002-8451-2913)
- Christoph Kuppe (ORCID: https://orcid.org/0000-0003-4597-9833)
- Joachim Jankowski (ORCID: https://orcid.org/0000-0002-4528-2967)
- Janina Frisch (ORCID: https://orcid.org/0009-0003-9344-1728)
- Susanne Ziegler
Institutions
- Maastricht University (NL)
- Franziskushospital Aachen (DE)
- Cardiff University (GB)
- RWTH Aachen University (DE)
- Saarland University (DE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1111/apha.70040
- Citations
- 3
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.36
Funders
- Deutsche Forschungsgemeinschaft