Glofitamab results in cost savings versus epcoritamab in relapsed/refractory diffuse large B-cell lymphoma: a total cost of care analysis ^‡

Fixed-treatment duration glofitamab and treat-to-progression epcoritamab are approved in the US for diffuse large B-cell lymphoma (DLBCL) after ≥2 prior therapies. An economic model was developed to estimate the per-patient total cost of care (TCC) for glofitamab versus epcoritamab from a US healthcare perspective. Treatment costs were based on time-to-off-treatment (glofitamab, NCT03075696) and progression-free survival (epcoritamab, NCT03625037). Per-patient cost savings, adjusted to 2023 US dollars, were observed with glofitamab versus epcoritamab across cycles 1-3 (-$56,275), and over 6 months (-$37,982), 1 year (-$68,195), 5 years (-$223,692), 10 years (-$325,175), and lifetime (-$503,075). While adverse event ($364) and treatment administration ($8,398) costs were higher for glofitamab versus epcoritamab, these were offset by consistently lower glofitamab treatment costs across all time horizons. Glofitamab showed per-patient TCC savings versus epcoritamab at every cumulative cycle and across all time horizons investigated, offering greater budget predictability and cost savings at the healthcare system and population levels.