Evaluation of the Effect of Ginger Zingiber Officinale Extract on Liver of Albino Rat Administered with Graded Doses of Piroxicam

This study aimed to evaluate the effects of Zingiber officinale (ginger) extract on the liver when administered with graded doses of piroxicam. Fifty albino rats were divided into five groups (A–E) of ten each. Group A served as the control, while Group B received 2.7 mg/kg of piroxicam, Group C was given 400 mg/kg of ginger, Group D received 2.7 mg/kg of piroxicam and 100 mg/kg of ginger, and Group E was administered 2.7 mg/kg of piroxicam along with 400 mg/kg of ginger. Substances were administered daily for 21 days, and the weights of both test and control animals were monitored. After treatment, the rats were anesthetized with chloroform, and their livers were harvested for immunohistochemistry processing. ANOVA was used for statistical analysis, with significance set at P < 0.05. Data were expressed as Mean ± SEM, with control group weight values recorded as 247.00 ± 3.35 at baseline, 219 ± 9.36 after acclimatization, and 219 ± 6.40 before sacrifice. No significant differences (p < 0.05) were found between the test groups and the control. Histological analysis revealed leukocyte infiltration in the liver of Group B (piroxicam 2.7 mg/kg) and leukocyte deposition in Group C (ginger 400 mg/kg). Group D (piroxicam 2.7 mg/kg + ginger 100 mg/kg) exhibited cellular changes and tissue damage, while Group E (piroxicam 2.7 mg/kg + ginger 400 mg/kg) showed neoplastic changes. Further research is recommended to accurately determine the effects of varying doses of Zingiber officinale on piroxicam-induced liver alterations