Antitumor Activity of Vebreltinib and Characterization of Clinicogenomic Features in Solid Tumors with <i>MET</i> Rearrangements
MET rearrangement-positive cancers are not well-characterized, and optimal treatment strategies are yet to be defined. Through comprehensive genomic analysis, preclinical modeling, and preliminary results of a phase II clinical trial, we demonstrate that MET fusions are a unique molecular subtype of cancers targetable with vebreltinib, a TKI in development.
Authors
- Dimitris Gazgalis (ORCID: https://orcid.org/0009-0002-2762-6989)
- William W. Feng (ORCID: https://orcid.org/0000-0002-8976-5020)
- Jie Jiang (ORCID: https://orcid.org/0000-0003-3795-672X)
- Francesco Facchinetti (ORCID: https://orcid.org/0000-0001-6313-6341)
- Federica Pecci (ORCID: https://orcid.org/0009-0000-9289-2007)
- Edoardo Garbo (ORCID: https://orcid.org/0000-0003-2394-9895)
- Kin-Hung P. Yu (ORCID: https://orcid.org/0000-0002-9246-4368)
- Igor Odintsov (ORCID: https://orcid.org/0000-0001-8073-8803)
- Benjamin Besse (ORCID: https://orcid.org/0000-0001-5090-8189)
- David Planchard (ORCID: https://orcid.org/0000-0002-1565-8310)
- Biagio Ricciuti (ORCID: https://orcid.org/0000-0002-0651-2678)
- Sani H. Kizilbash (ORCID: https://orcid.org/0000-0001-8568-1519)
- Yusuke Sato (ORCID: https://orcid.org/0000-0001-8495-8950)
- Alexis B. Cortot (ORCID: https://orcid.org/0000-0003-0098-2238)
- Danielle Haradon (ORCID: https://orcid.org/0009-0006-2613-3866)
- Emilio Esteban (ORCID: https://orcid.org/0000-0002-2980-5254)
- Jiaxin Niu (ORCID: https://orcid.org/0000-0001-9018-287X)
- Pasi Antero Janne (ORCID: https://orcid.org/0000-0002-7821-4928)
- Pascale Tomasini (ORCID: https://orcid.org/0000-0002-6474-5912)
- Pernelle Lavaud (ORCID: https://orcid.org/0000-0002-1286-5955)
- Mihaela D. Aldea (ORCID: https://orcid.org/0000-0001-7685-051X)
- Jordi Remón (ORCID: https://orcid.org/0000-0002-9462-875X)
- Antoîne Italiano (ORCID: https://orcid.org/0000-0002-8540-5351)
- Koji Haratani (ORCID: https://orcid.org/0000-0002-1767-6854)
- Marcia Cruz‐Correa (ORCID: https://orcid.org/0000-0001-8147-7457)
- Lodovica Zullo (ORCID: https://orcid.org/0000-0002-1659-788X)
- Alessandro Di Federico (ORCID: https://orcid.org/0000-0001-8877-4315)
- Simon Baldacci (ORCID: https://orcid.org/0000-0003-3610-1316)
- Scott Owen (ORCID: https://orcid.org/0000-0002-9745-0555)
- Anna Rachel Minchom (ORCID: https://orcid.org/0000-0002-9339-7101)
- Damien Vasseur (ORCID: https://orcid.org/0000-0001-8787-1498)
- Malini Gandhi (ORCID: https://orcid.org/0000-0002-8006-4148)
- Jianwei Che (ORCID: https://orcid.org/0000-0003-4956-4811)
- Martin Förster (ORCID: https://orcid.org/0000-0003-3876-7269)
- Felix H. Gottlieb (ORCID: https://orcid.org/0009-0000-1451-8167)
- Arushi Saini (ORCID: https://orcid.org/0000-0003-1917-4468)
- Joao V. Alessi (ORCID: https://orcid.org/0000-0002-8072-5946)
- Maisam Makarem (ORCID: https://orcid.org/0000-0002-5659-1095)
- Mark M. Awad (ORCID: https://orcid.org/0000-0003-0928-5244)
- Marie-Anaïs Locquet (ORCID: https://orcid.org/0009-0000-2417-9912)
- Lynette M. Sholl (ORCID: https://orcid.org/0000-0002-9532-9735)
- Seshiru Nakazawa (ORCID: https://orcid.org/0000-0001-6218-9396)
- Pan Chen
- Xiaoling Zhang (ORCID: https://orcid.org/0009-0007-8729-7124)
- Kevin Tay (ORCID: https://orcid.org/0000-0003-2301-0183)
- Y. Watanabe
- Hoda A. Mahran
- Leong Swan Swan
- Mythili Sangem
Institutions
- University of London (GB)
- Brigham and Women's Hospital (US)
- Centre National de la Recherche Scientifique (FR)
- Royal Marsden NHS Foundation Trust (GB)
- Mayo Clinic (US)
- University College London Hospitals NHS Foundation Trust (GB)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Sciences Po Bordeaux (FR)
- Institute of Cancer Research (GB)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Gunma University (JP)
- University of Puerto Rico System (PR)
- Aix-Marseille Université (FR)
- Tottori University of Environmental Studies (JP)
- Université de Lille (FR)
- Université Paris-Saclay (FR)
- Institut Pasteur de Lille (FR)
- Royal London Hospital (GB)
- American University of Puerto Rico (PR)
- McGill University Health Centre (CA)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centro Oncológico de Galicia (ES)
- Dana-Farber Cancer Institute (US)
- Apollomics (United States) (US)
- Mayo Clinic in Arizona (US)
- Hospital Universitario Central de Asturias (ES)
- Institut Bergonié (FR)
- National Cancer Centre Singapore (SG)
- Hôpital de la Timone (FR)
- Bicêtre Hospital (FR)
- Banner MD Anderson Cancer Center
- University College London (GB)
- Tottori University (JP)
- International University of Health and Welfare (JP)
- University of Bologna (IT)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1726
- Citations
- 5
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 6.61