Correlation Between Lipid Profile and Thyroid Dysfunction in a Tertiary Care Hospital

Background: Thyroid hormones, which are categorized as catabolic hormones, have been found to regulate several metabolic functions, including the synthesis, mobilization, and breakdown of lipids.The total risk of CVD is influenced by thyroid hormones, which have a major impact on lipoprotein metabolism and certain risk factors for CVD.The aim is to find the relation between thyroid dysfunctions and lipid profile parameters in a tertiary care hospital.Methods: The study is cross-sectional.A completely automated biochemistry analyzer was used to evaluate HDL cholesterol, triglycerides, and total cholesterol.A chemiluminescence assay was used to assess serum T3, T4, and TSH.Lipid ratio and thyroid hormone were correlated.Results: The majority (40%) were in the 41-50 age range, and the majority were female (62.3%).The hypothyroid group had significantly greater average serum levels of TC, TG, VLDL, LDL cholesterol, and LDL/HDL ratio than the euthyroid group, while the hypothyroid group had significantly lower mean HDL levels than the euthyroid group (p<0.05).The hyperthyroid group had significantly lower mean serum levels of TC, TG, VLDL, LDL cholesterol, and LDL/HDL ratio than the euthyroid group (p<0.05),while the hyperthyroid group had significantly higher mean HDL levels (p<0.05). Conclusion:All individuals with thyroid dysfunction should have their lipid profiles screened, and any underlying lipid problems must be found and addressed.