Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea
We conclude that Notum and Wnt5a are necessary for proper tracheal cartilage patterning by coordinating timely chondrogenesis. Thus, these studies shed light on molecular mechanisms underlying congenital anomalies of the trachea.
Authors
- Yan Xu (ORCID: https://orcid.org/0009-0001-4936-7132)
- Natalia Bottasso-Arias (ORCID: https://orcid.org/0000-0002-3553-6978)
- Débora Sinner (ORCID: https://orcid.org/0000-0002-0704-5223)
- Yixin Wu (ORCID: https://orcid.org/0009-0002-5412-4589)
- Megha Mohanakrishnan (ORCID: https://orcid.org/0000-0002-1312-1456)
- Nicholas X. Russell (ORCID: https://orcid.org/0000-0003-3901-2378)
- Kaulini Burra (ORCID: https://orcid.org/0000-0002-9107-187X)
- Sarah Trovillion
Institutions
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fcell.2025.1523833
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00