Sometimes less is more: avidity-dependent transport of targeted polymersomes across the blood–brain-barrier
Targeted PEG- b -PLA polymersomes safely transport anticancer drugs for glioblastoma treatment, with low ligand valency formulations showing superior blood–brain barrier (BBB) permeation compared to high-valency designs.
Authors
- Peter Pfeifer (ORCID: https://orcid.org/0000-0002-6773-5584)
- Íris L. Batalha (ORCID: https://orcid.org/0000-0002-7917-3865)
- Cláudia Nunes (ORCID: https://orcid.org/0000-0002-1502-3710)
- Salette Reis (ORCID: https://orcid.org/0000-0002-0736-2835)
- Paulo Costa (ORCID: https://orcid.org/0000-0002-1152-3398)
- Domingos Ferreira (ORCID: https://orcid.org/0000-0001-6200-7169)
- Andreia Marinho (ORCID: https://orcid.org/0000-0003-0743-666X)
- Marta Correia‐da‐Silva (ORCID: https://orcid.org/0000-0003-4150-8532)
- Carlos Lopes (ORCID: https://orcid.org/0000-0001-7805-412X)
- Giuseppe Battaglia (ORCID: https://orcid.org/0000-0001-7571-3417)
- Ana Catarina Alves (ORCID: https://orcid.org/0000-0003-1884-2161)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Universidade do Porto (PT)
- Institute of Marine Research (PT)
- Rede de Química e Tecnologia (PT)
- Institute for Bioengineering of Catalonia (ES)
- University of Bath (GB)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4pm00338a
- Citations
- 1
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- “la Caixa” Foundation
- European Commission
- Applied Molecular Biosciences Unit
- Centro Interdisciplinar de Investigação Marinha e Ambiental
- Rede de Química e Tecnologia
- HORIZON EUROPE Framework Programme
- Fundação para a Ciência e a Tecnologia