The Effect of Kisspeptin-10 on Cisplatin-Induced Testicular Oxidative Stress
Objective: Cisplatin, one of the anticarcinogenic drugs, causes damage to spermatogenic cells, sertoli cells and leydig cells. This study aimed to investigate the kisspeptin-10 effect against oxidative stress caused by cisplatin in male reproductive organs and its negative effects on spermatological parameters. Materials and Methods: In the experiment, 34 male Sprague Dawley rats were used. Rats were divided into 4 groups as control, cisplatin, Kisspeptin-10 and cisplatin+kisspeptin-10. Cisplatin 5 mg/kg/single dose and Kisspeptin-10 50 nmol/kg dose were administered intraperitoneally for 7 days. Results: In the cisplatin group, testicular malondialdehyde level increased (p
Authors
- Mesut Aksakal (ORCID: https://orcid.org/0000-0002-6230-2413)
- Fatma Beril Koçyiğit (ORCID: https://orcid.org/0000-0001-5659-394X)
- Gözde Arkalı (ORCID: https://orcid.org/0000-0002-0850-7557)
- Abdurrauf Yüce (ORCID: https://orcid.org/0000-0003-2928-5970)
- Meltem Kızıl (ORCID: https://orcid.org/0000-0001-6547-6809)
- Tutku Can Acısu (ORCID: https://orcid.org/0000-0002-0882-937X)
- Edanur Güler Ekmen (ORCID: https://orcid.org/0000-0001-8473-7592)
- Mehmet Çay (ORCID: https://orcid.org/0000-0003-3896-0042)
Institutions
- Fırat University (TR)
- Harran University (TR)
Publication Details
- Journal
- Balıkesır Health Sciences Journal
- Published
- 2025-03-28
- DOI
- https://doi.org/10.53424/balikesirsbd.1609836
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00