Hemato- Biochemical Profile of Malaria Patients in Sub Saharan Africa: A Case of the Urban Health Center of Franceville, Gabon

Hemato-biochemical analysis is essential for optimal management, reducing the mortality and sequelae of malaria, particularly in endemic areas such as Gabon. This cross-sectional study examined hematological and biochemical changes associated with malaria in 154 patients at the Franceville Urban Health Center (July-September 2024). A high malaria prevalence of 66.88% (95% CI: 0.6-0.74), a severe reduction in erythrocytes (OR=16.59, 95% CI[6.82-43.94], p<0.001), elevated leukocytes (OR=5.6, 95% CI[2.57-2.7], p<0.001), marked thrombocytopenia (OR=15.59, 95% CI[5.86-49.3], p<0. 001), a significant increase in ALT (OR=6.67, 95% CI [3.85-20.47], p<0.001), an increase in AST in 42.21% of patients (OR=0.37, 95% CI [0.14-0.88], p<0.001), and finally, an increase in CRP levels (OR=0.6, 95% CI [0.28-1.26], p<0.001), were found as results. This study demonstrates the profound effects of malaria on the hematopoietic and hepatic systems, underlining the need for comprehensive monitoring of these parameters in clinical management.