529. Thalamo-Cortical Structural Co-Variation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An Enigma Study
Structural brain differences in thalamus and cortex have been widely reported in schizophrenia (SCZ) relative to neurotypical controls (NC), yet most studies focused on the thalamus as a whole, single region-of-interest. Additionally, findings in individuals at familial high-risk for schizophrenia (FHR) remain inconclusive. Here, we investigated whether local and global thalamic-related structural alterations (respectively, volumes of thalamic subdivisions and thalamo-cortical/cortico-cortical co-variation) vary as a function of familial risk for schizophrenia.
Authors
- Alessandro Bertolino (ORCID: https://orcid.org/0000-0002-1251-1380)
- Jessica A. Turner (ORCID: https://orcid.org/0000-0003-0076-8434)
- Godfrey D. Pearlson (ORCID: https://orcid.org/0000-0002-7525-5185)
- Young‐Chul Chung (ORCID: https://orcid.org/0000-0001-9491-1822)
- Machteld Marcelis (ORCID: https://orcid.org/0000-0003-0045-9244)
- Annalisa Lella
- Fabrizio Piras (ORCID: https://orcid.org/0000-0003-3566-5494)
- Oliver Gruber (ORCID: https://orcid.org/0000-0003-1841-7413)
- Scott R. Sponheim (ORCID: https://orcid.org/0000-0002-2782-0856)
- Giulio Pergola (ORCID: https://orcid.org/0000-0002-9193-1841)
- Felice Iasevoli (ORCID: https://orcid.org/0000-0002-7051-5013)
- Udo Dannlowski (ORCID: https://orcid.org/0000-0002-0623-3759)
- Tilo T. J. Kircher (ORCID: https://orcid.org/0000-0002-2514-2625)
- Kang Sim (ORCID: https://orcid.org/0000-0003-3209-9626)
- David C. Glahn (ORCID: https://orcid.org/0000-0002-4749-6977)
- Tamsyn E. Van Rheenen (ORCID: https://orcid.org/0000-0003-3339-6665)
- Taeyoung Lee (ORCID: https://orcid.org/0000-0002-1657-678X)
- Linda A. Antonucci (ORCID: https://orcid.org/0000-0002-7919-7402)
- Gisela Sugranyes (ORCID: https://orcid.org/0000-0002-2545-7862)
- Melissa J. Green (ORCID: https://orcid.org/0000-0002-9361-4874)
- Theo G.M. van Erp (ORCID: https://orcid.org/0000-0002-2465-2797)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Edith Pomarol-Clotet
Institutions
- University of Southern California (US)
- Boston Children's Hospital (US)
- The University of Sydney (AU)
- Johns Hopkins University (US)
- Philipps University of Marburg (DE)
- The University of Melbourne (AU)
- University of California, Irvine (US)
- Heidelberg University (DE)
- University of Münster (DE)
- Johns Hopkins Medicine (US)
- University of Minnesota System (US)
- The Ohio State University Wexner Medical Center (US)
- Kyungpook National University (KR)
- Yale University (US)
- Maastricht University (NL)
- Federico II University Hospital (IT)
- Fidmag Sisters Hospitallers (ES)
- Hospital Mare de Déu de la Mercè (ES)
- Institute of Mental Health (SG)
- Cognitive Neuroimaging Lab (FR)
- Fondazione Santa Lucia (IT)
- Boston Children's Museum (US)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University of Bari Aldo Moro (IT)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.biopsych.2025.02.768
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00