Bone Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology
Ewing sarcoma and osteosarcoma constitute 36% of all primary bone cancers. However, these 2 subtypes represent the most commonly diagnosed bone cancer types in the pediatric and adolescent population. Although still largely unknown, certain genetic mutations, rearrangements, and/or predisposition syndromes likely play a role in the pathogenesis of bone cancer. Osteosarcoma may also develop as a direct result of the long-term side effects of radiation therapy. With the implementation of a multimodality approach to treatment, including multiagent neoadjuvant and adjuvant chemotherapy regimens, targeted therapy options, surgery, and radiation, individuals with Ewing sarcoma and osteosarcoma are showing higher cure rates and improved overall survival. The NCCN Guidelines for Bone Cancer provide a consensus and evidence-based framework for the workup, management, and surveillance of local and recurrent/metastatic disease.
Authors
- Michael J. Ferguson (ORCID: https://orcid.org/0000-0002-1398-7217)
- Carol D. Morris (ORCID: https://orcid.org/0000-0002-4007-9476)
- Susan M. Hiniker (ORCID: https://orcid.org/0000-0003-4723-2151)
- Nicholas Matthew Bernthal (ORCID: https://orcid.org/0000-0003-3338-5878)
- Lisa E. Hang
- John Groundland (ORCID: https://orcid.org/0000-0001-5921-8301)
- Breelyn A. Wilky (ORCID: https://orcid.org/0000-0001-5080-497X)
- Herbert S. Schwartz (ORCID: https://orcid.org/0000-0001-6591-8179)
- Rosanna L. Wustrack (ORCID: https://orcid.org/0000-0001-8512-5344)
- Brian E. Brigman (ORCID: https://orcid.org/0000-0003-3835-048X)
- Angela C. Hirbe (ORCID: https://orcid.org/0000-0003-1719-0771)
- Robert L. Satcher (ORCID: https://orcid.org/0000-0003-3356-4331)
- Jessica Davis (ORCID: https://orcid.org/0000-0003-2241-8961)
- Shivani Ahlawat (ORCID: https://orcid.org/0000-0003-4437-5237)
- Eric D. Donnelly (ORCID: https://orcid.org/0000-0001-6028-7128)
- Janet Yoon
- Steven W. Thorpe (ORCID: https://orcid.org/0000-0003-3127-4912)
- Brandon W. Jonard (ORCID: https://orcid.org/0000-0002-6979-1942)
- Cara A. Cipriano (ORCID: https://orcid.org/0000-0002-1609-9899)
- Joseph Kuechle (ORCID: https://orcid.org/0000-0001-9619-3510)
- Alexandra K. Callan (ORCID: https://orcid.org/0000-0002-2680-0554)
- Odion T. Binitie (ORCID: https://orcid.org/0000-0002-2674-9939)
- Lee D. Cranmer
- Margo Hoover‐Regan (ORCID: https://orcid.org/0000-0002-6804-1218)
- Sean V. McGarry
- Dieter M. Lindskog (ORCID: https://orcid.org/0000-0002-6033-5297)
- Rebecca M. Shulman (ORCID: https://orcid.org/0000-0003-3309-0922)
- Daniel J. Olson (ORCID: https://orcid.org/0000-0001-8902-7661)
- Sarah G Boles (ORCID: https://orcid.org/0000-0002-9956-4767)
- Jason L. Hornick (ORCID: https://orcid.org/0000-0001-6475-8345)
- Peter S. Rose (ORCID: https://orcid.org/0000-0001-7705-3432)
- Victor M. Santana (ORCID: https://orcid.org/0000-0003-0320-5776)
- Joel Mayerson (ORCID: https://orcid.org/0000-0002-0503-714X)
- Matthew Hess
- Megan Lyons
- J. Sybil Biermann
- Ann Graham
- Frankie Jones
- Nicholas Sansone
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Barnes-Jewish Hospital (US)
- City Of Hope National Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Tennessee Health Science Center (US)
- Breast Cancer Research Foundation (US)
- University of Utah (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- UC San Diego Health System (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Susan Thompson Buffett Foundation (US)
- WinnMed (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- Jewish Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- University of Colorado Cancer Center (US)
- Dana-Farber Brigham Cancer Center (US)
- Smilow Cancer Hospital (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Moores Cancer Center
- University of Chicago Medicine Comprehensive Cancer Center
- UCLA Jonsson Comprehensive Cancer Center
- Vanderbilt-Ingram Cancer Center
- Stanford Cancer Institute
- Duke Cancer Institute
- Fred and Pamela Buffett Cancer Center
- UC Davis Comprehensive Cancer Center
- Harold C. Simmons Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- National Comprehensive Cancer Network
- Indiana University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2025-04-01
- DOI
- https://doi.org/10.6004/jnccn.2025.0017
- Citations
- 27
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 41.00