Cancer vulnerabilities exposed by finding interactions among DNA repair factors

A screen of interactions between genes involved in the cell’s response to DNA damage has revealed several previously unreported ‘synthetic lethalities’, in which disrupting a pair of genes, but not either gene alone, causes cell death. The resulting map of genetic interactions could help to identify therapeutic targets for cancer. A screen of almost 150,000 pairwise combinations of genes could help to identify targets for cancer treatment.

Publication Details

Journal
Nature
Published
2025-04-09
DOI
https://doi.org/10.1038/d41586-025-01049-4
Primary Topic
DNA Repair Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Cancer vulnerabilities exposed by finding interactions among DNA repair factors

Nature
DNA Repair Mechanisms
article

Cancer vulnerabilities exposed by finding interactions among DNA repair factors

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Abstract

A screen of interactions between genes involved in the cell’s response to DNA damage has revealed several previously unreported ‘synthetic lethalities’, in which disrupting a pair of genes, but not either gene alone, causes cell death. The resulting map of genetic interactions could help to identify therapeutic targets for cancer. A screen of almost 150,000 pairwise combinations of genes could help to identify targets for cancer treatment.

Nature
Openalex Percentile: Top 94%
DNA Repair Mechanisms
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Cancer vulnerabilities exposed by finding interactions among DNA repair factors · Nature (2025) | TGRS Research Map | TGRS