Role of Genomics and Proteomics in Alzheimer’s Disease

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline, and its underlying mechanisms involve intricate interactions between genetic and proteomic factors. Genomics and proteomics play a crucial role in understanding Alzheimer’s disease by identifying genetic risk factors. Recent advancements in genomics and proteomics have enabled researchers to develop deeper into the molecular pathways implicated in AD. Genomic studies have uncovered various genetic variants associated with increased risk for AD, particularly in genes such as APP, APOE, TREM2, CLU, CD33, PSEN1 & 2 proteins like Aβ, Tau. Our current understanding of AD pathologies involves various hypotheses, such as the cholinergic, amyloid, tau protein, inflammations, etc. Keywords: Alzheimer's disease, Genes (APP, APOE, CLU, TREM2, CD33, PSEN1&2), Proteins (Aβ, Tau