A combination of Dihydroartemisinin and Venetoclax enhances antitumor effect in AML via C-MYC/BCL-XL/MCL-1 triple targeting
The findings suggest that the combination of VEN and DHA exerts synergistic anti-leukemic effects by targeting BCL-XL, MCL-1 and C-MYC, offering a promising therapeutic strategy for AML.
Authors
- Jiaying Lian
- Fenglin Li (ORCID: https://orcid.org/0000-0001-7932-0071)
- Peipei Ye
- Dong Chen (ORCID: https://orcid.org/0000-0001-7627-9560)
- Chen Yao (ORCID: https://orcid.org/0000-0003-0327-9599)
- Yuyu Lu
- Ying Lu (ORCID: https://orcid.org/0000-0003-2960-3131)
- Shuangyue Li (ORCID: https://orcid.org/0000-0003-2897-4205)
- Haihui Zhuang
- Renzhi Pei
Institutions
- Ningbo University (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1007/s12672-025-02242-7
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 3.54
Funders
- Natural Science Foundation of Ningbo