Disentangling effects of the DR and DQ isomers encoded by the HLA class II haplotype DRB1*15:01/DQB1*06:02 to help establish the true risk allele for FVIII inhibitor development in Hemophilia A
Our results suggest that DRB1*15:01 is the offending HLAII allele and that DR15 allotypes underlie the increased FEI risk in HAPs.
Authors
- Bernadette W. Luu
- John Blangero (ORCID: https://orcid.org/0000-0001-6250-5723)
- Jacob A. Galán (ORCID: https://orcid.org/0000-0003-3304-0474)
- Marcio Almeida (ORCID: https://orcid.org/0000-0002-8114-3892)
- Raja Rajalingam (ORCID: https://orcid.org/0000-0001-8821-7877)
- Long V. Dinh
- Juan M. Peralta (ORCID: https://orcid.org/0000-0002-8811-5579)
- Marco H. Hofmann (ORCID: https://orcid.org/0000-0001-7557-1156)
- Tom E. Howard (ORCID: https://orcid.org/0000-0002-4550-278X)
- Eugene Maraskovsky (ORCID: https://orcid.org/0000-0003-3690-6253)
- Henry Mead
- Eli J. Fine (ORCID: https://orcid.org/0000-0002-5745-4498)
- Eron G. Manusov (ORCID: https://orcid.org/0000-0002-6052-1823)
- Miguel A. Escobar (ORCID: https://orcid.org/0000-0002-2944-0240)
- Joanne E. Curran (ORCID: https://orcid.org/0000-0002-6898-155X)
- Satish Kumar (ORCID: https://orcid.org/0000-0002-1969-4431)
- Vincent P. Diego (ORCID: https://orcid.org/0009-0008-3735-6912)
- Paul Lehmann
- Sarah Williams‐Blangero
- Jerry S. Powell
- Harald H.H. Göring
- Huy Huynh
- Anne M. Verhagen
Institutions
- University of California, San Francisco (US)
- The University of Texas Rio Grande Valley (US)
- Shaker Heights Public Library (US)
- Brownsville Public Library (US)
- Valley Baptist Medical Center (US)
- CSL (Australia) (AU)
- Indiana Hemophilia and Thrombosis Center (US)
- Case Western Reserve University (US)
- University of California, Davis (US)
- BioMarin (United States) (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-04-09
- DOI
- https://doi.org/10.3389/fgene.2025.1506862
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00