Low Protein Diet Exacerbates Experimental Mouse Models of Colitis through Epithelial Autonomous and Nonautonomous Mechanisms
Our study demonstrates a complex interplay between dietary protein, epithelial mTORC1 signaling, and gut microbiota in modulating IBD pathogenesis and highlights the potential for targeted dietary strategies, including amino acid supplementation, to improve disease management in patients with IBD.
Authors
- Cristina Castillo (ORCID: https://orcid.org/0000-0003-1323-6875)
- Scott F. Leiser (ORCID: https://orcid.org/0000-0002-8003-2955)
- Varun Ponnusamy
- Ryan J. Rebernick (ORCID: https://orcid.org/0000-0002-5532-581X)
- Yatrik M. Shah (ORCID: https://orcid.org/0000-0002-2487-4816)
- Sumeet Solanki (ORCID: https://orcid.org/0000-0002-2773-3082)
- Thomas Schmidt (ORCID: https://orcid.org/0000-0003-4977-8414)
- Joseph Taranto (ORCID: https://orcid.org/0000-0003-1997-6399)
- Jun Hee Lee (ORCID: https://orcid.org/0000-0002-2200-6011)
- M. Sykes
Institutions
- University of Michigan (US)
- University Medical Center (US)
- Michigan United (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.tjnut.2025.03.031
- Citations
- 2
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 3.63