Complex endoscopic treatment of pancreatic cancer complications: A case report

Pancreatic cancer remains one of the most lethal malignancies, with a persistently low five-year survival rate and substantial global mortality. Surgery remains the only curative option, but most patients are not surgical candidates at diagnosis, and palliative radiotherapy and chemotherapy remain the only ways to improve survival. The progression of pancreatic adenocarcinoma is often associated with complications, such as biliary obstruction and gastric outlet obstruction (GOO). This case report describes a 57-year-old male patient with pancreatic ductal adenocarcinoma who underwent successful endoscopic management of common complications associated with the disease. These included biliary obstruction, treated with EUS-guided hepaticogastrostomy and EUS-guided gallbladder drainage, and gastric outlet obstruction, managed through endoscopic gastroenterostomy. Through this clinical case, we aim to demonstrate that minimally invasive interventions not only relieve symptoms but also improve the patient’s quality of life, emphasizing the evolving role of endoscopy in the therapeutic management of pancreatic ductal adenocarcinoma. These challenges underscore the importance of a multidisciplinary approach to optimize therapeutic strategies.