Investigation of Platelet Functional Disorders in Hereditary Thrombocytopenias with Predisposition to Hematologic Malignancies in Children by Flow Cytometry

Introduction: Hereditary thrombocytopenias are variable in the severity of bleeding, the count and size of platelets, which is related with the number of receptors and intracellular structure.So, the healthy reference ranges do not allow interpretation of functional disorders, especially in macro-and micro-thrombocytopenias.The diagnostic approach based on the flow cytometry allowing to use the reference values for these patients is necessary.