<scp>EEG</scp> signal dimension is an index of seizure propensity and antiseizure medication effects in a mouse model of acquired epilepsy
EEG-based dimension provides a reliable measure of mouse propensity to experience seizures as well as ASM efficacy, regardless of seizure rates. Measuring dimension variation should facilitate the inclusion of subjects with low seizure rate in preclinical and clinical trials while also shortening the periods of monitoring. This could accelerate both the development of new treatments and therapeutic decisions in the medical field.
Authors
- Alessandro Giuliani (ORCID: https://orcid.org/0000-0002-4640-804X)
- Massimo Rizzi (ORCID: https://orcid.org/0000-0002-5477-2263)
- Peter J. West (ORCID: https://orcid.org/0000-0002-5774-5180)
- Annamaria Vezzani (ORCID: https://orcid.org/0000-0003-0573-6175)
- Karen S. Wilcox (ORCID: https://orcid.org/0000-0003-2660-8826)
Institutions
- Mario Negri Institute for Pharmacological Research (IT)
- University of Utah (US)
- Istituto Superiore di Sanità (IT)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1111/epi.18397
- Primary Topic
- Neural dynamics and brain function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke