ARHGEF3 coordinates adipocyte hypertrophy and differentiation through dual YAP-RhoA and PPARγ activation
ARHGEF3 emerges as a pivotal regulator of adipocyte dynamics by coordinating YAP-RhoA signaling and enhancing PPARγ activity. These findings offer novel therapeutic insights for addressing obesity and related metabolic disorders.
Authors
- Shi‐Young Park
- Sana Abdul Khaliq (ORCID: https://orcid.org/0000-0002-0724-0336)
- Yoonil Cho
- Cheol Soo Choi (ORCID: https://orcid.org/0000-0001-9627-058X)
- Je Kyung Seong (ORCID: https://orcid.org/0000-0003-1177-6958)
- Mee‐Sup Yoon (ORCID: https://orcid.org/0000-0002-0114-1142)
- Seungyoon Nam (ORCID: https://orcid.org/0000-0002-0966-7915)
- Jie Chen (ORCID: https://orcid.org/0000-0002-7887-3747)
- Miseon Lee (ORCID: https://orcid.org/0000-0002-6385-7621)
- Syeda Maham
Institutions
- Gachon University (KR)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.jare.2025.04.010
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15