Characterization of the Molecular Mechanisms Underlying Lurasidone‐Induced Acute Manic Episodes in Bipolar Depression: A Network Pharmacology and Molecular Docking Approach
This study revealed that lurasidone may regulate the serotonergic synapse signaling pathway by interacting with the identified core targets MAOB, HTR1A, HTR2A, HTR3A, SLC18A2, HTR1B, and HTR7 to induce treatment-emergent mania in people with bipolar depression. Our work provides a theoretical basis for the pharmacology of lurasidone-induced acute mania in bipolar depression and further basic research.
Authors
- Ranli Li
- Jia Feng (ORCID: https://orcid.org/0000-0001-9968-2360)
- Chuanjun Zhuo (ORCID: https://orcid.org/0000-0002-3793-550X)
- Chao Li (ORCID: https://orcid.org/0000-0002-0240-5170)
- Lina Wang (ORCID: https://orcid.org/0009-0002-8518-8032)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-4082-5026)
- Qiuyu Zhang (ORCID: https://orcid.org/0000-0002-4823-5031)
- Lei Yang (ORCID: https://orcid.org/0009-0000-1662-3438)
- Xiaoyan Ma (ORCID: https://orcid.org/0009-0007-7953-947X)
- Hongjun Tian (ORCID: https://orcid.org/0000-0002-3919-3749)
Institutions
- Nankai University (CN)
- Tianjin Anding Hospital (CN)
- Tianjin Fourth Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70383
- Citations
- 2
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China