Extracellular vesicles in osteoarthritis synovial fluid contain both transmembrane and intravesical TNF-α
While intravesical TNF-α may evade TNF-α inhibitors, TNF-α carried by EVs retains pathogenic potential, either by activating pro-inflammatory pathways via TM-TNF-α receptor engagement on target cells, or through the transfer of TNF-α cargo to recipient cells.
Authors
- Virginia B. Kraus (ORCID: https://orcid.org/0000-0001-8173-8258)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-7390-4439)
Institutions
- Duke University (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100612
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Institute on Aging
- Duke Cancer Institute