The design and rationale of the Biomarkers for Evaluating Spine Treatments trial: a sequential multiple assignment randomized trial
The Biomarkers for Evaluating Spine Treatments (BEST) trial is registered on ClinicalTrials.gov (Registration number: NCT05396014; https://clinicaltrials.gov/study/NCT05396014).
Authors
- Sean Mackey (ORCID: https://orcid.org/0000-0001-7744-5348)
- Chelsea Kaplan (ORCID: https://orcid.org/0000-0001-9324-655X)
- Daniel J. Clauw (ORCID: https://orcid.org/0000-0002-8114-7818)
- Kelly Stephenson Barth (ORCID: https://orcid.org/0000-0001-6339-6573)
- John Sperger (ORCID: https://orcid.org/0000-0002-2273-5353)
- Steven E. Harte (ORCID: https://orcid.org/0000-0002-2929-8694)
- Jeffrey J. Borckardt (ORCID: https://orcid.org/0000-0001-5761-8125)
- Aaron J. Fields (ORCID: https://orcid.org/0000-0001-6460-4506)
- Joel Castellanos (ORCID: https://orcid.org/0000-0002-7365-7260)
- Kevin M. Bell (ORCID: https://orcid.org/0000-0003-2099-413X)
- Kushang V. Patel (ORCID: https://orcid.org/0000-0002-8443-2876)
- Anton E. Bowden (ORCID: https://orcid.org/0000-0003-3124-7551)
- Afton L. Hassett (ORCID: https://orcid.org/0000-0003-2982-484X)
- Brooke A. Chidgey (ORCID: https://orcid.org/0000-0002-8902-2788)
- Richard E. Harris (ORCID: https://orcid.org/0000-0002-2067-8447)
- Anastasia Ivanova (ORCID: https://orcid.org/0000-0003-4321-2073)
- Beibo Zhao (ORCID: https://orcid.org/0000-0001-8355-7143)
- Scott Peltier (ORCID: https://orcid.org/0000-0002-6690-9757)
- Jeffrey C. Lotz
- Amber K Brooks (ORCID: https://orcid.org/0000-0001-9568-1336)
- Gwendolyn Sowa
- Jeannie F. Bailey (ORCID: https://orcid.org/0000-0003-4618-7512)
- Nam Vo (ORCID: https://orcid.org/0000-0002-1265-8921)
- David A. Williams (ORCID: https://orcid.org/0000-0002-5052-4895)
- Lucy Chen (ORCID: https://orcid.org/0000-0002-9956-8194)
- Kenneth A. Weber (ORCID: https://orcid.org/0000-0002-0916-9174)
- Anna Batorsky (ORCID: https://orcid.org/0000-0001-5644-0951)
- Bryce Rowland (ORCID: https://orcid.org/0000-0002-8900-6905)
- Gregorij Kurillo (ORCID: https://orcid.org/0000-0003-1211-6919)
- Rachel West Goolsby (ORCID: https://orcid.org/0000-0001-9744-967X)
- Robert W. Hurley (ORCID: https://orcid.org/0000-0001-6591-9390)
- Michael Schneider (ORCID: https://orcid.org/0000-0001-7190-3379)
- Michael R. Kosorok (ORCID: https://orcid.org/0000-0002-6070-9738)
- Jonathan S. Dufour (ORCID: https://orcid.org/0000-0002-5468-3033)
- Julie M. Fritz (ORCID: https://orcid.org/0000-0002-3599-1057)
- Conor O’Neill (ORCID: https://orcid.org/0000-0003-4456-9445)
- Ulrike H. Mitchell (ORCID: https://orcid.org/0000-0002-2298-8756)
- Anna Hoffmeyer
- Samuel A. McLean (ORCID: https://orcid.org/0000-0001-9482-3582)
- Matthew A. Psioda (ORCID: https://orcid.org/0000-0002-4450-6981)
- Micah McCumber (ORCID: https://orcid.org/0000-0003-2570-1180)
- Cameron A Gunn
- Vitaly Napadow (ORCID: https://orcid.org/0000-0003-1941-1750)
- Gregory G. Knapik
- Sara R. Piva (ORCID: https://orcid.org/0000-0002-1716-3151)
- Kelley M. Kidwell (ORCID: https://orcid.org/0000-0002-1717-4483)
- Carol M. Greco (ORCID: https://orcid.org/0000-0002-3078-2918)
- Ajay D. Wasan (ORCID: https://orcid.org/0000-0002-6394-6077)
- Tristan Weaver
- Wolf Mehling (ORCID: https://orcid.org/0000-0002-0932-9844)
- Diane Dalton
- Prasath Mageswaran (ORCID: https://orcid.org/0000-0003-0015-8812)
- Kevin J. Anstrom (ORCID: https://orcid.org/0000-0001-6452-2172)
- Sean D. Rundell (ORCID: https://orcid.org/0000-0003-0782-5999)
- Andrew Schrepf (ORCID: https://orcid.org/0000-0003-4291-0320)
- Jianren Mao (ORCID: https://orcid.org/0000-0003-0298-486X)
- Matthew C. Mauck (ORCID: https://orcid.org/0000-0001-6426-1590)
- Andrea L. Chadwick (ORCID: https://orcid.org/0000-0002-0570-9997)
- Remy Lobo (ORCID: https://orcid.org/0000-0002-6951-0143)
- Sharmila Majumdar
- Sara Jones Berkeley
- Timothy S. Carey
- Leslie Wilson
- William S. Marras
- Fadel Zeidan (ORCID: https://orcid.org/0000-0002-4310-1325)
- Mark S Wallace
- Sarah Bagaason
Institutions
- Brigham Young University (US)
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- Harvard University (US)
- University of Kansas (US)
- Medical University of South Carolina (US)
- University of San Diego (US)
- University of Pittsburgh (US)
- Palo Alto University (US)
- University of California, San Francisco (US)
- University of Washington (US)
- University of California, Irvine (US)
- University of Utah (US)
- University of Michigan (US)
- Spaulding Rehabilitation Hospital (US)
- The University of Kansas Health System (US)
- The Ohio State University Wexner Medical Center (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- GlaxoSmithKline (United States) (US)
- Michigan Medicine (US)
- Durham VA Health Care System (US)
- The Spine Institute (US)
- Stanford Medicine (US)
- Samueli Institute (US)
- Center for Pain and the Brain (US)
- GlaxoSmithKline (Spain) (ES)
- Center for Systems Biology (US)
- Wake Forest University (US)
- The Ohio State University (US)
Publication Details
- Journal
- Pain Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1093/pm/pnaf032
- Citations
- 5
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 6.97
Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases