Exercise, quality of life and chemotherapy-induced peripheral neuropathy in cancer patients and survivors

Background: With advances in cancer treatment, survival rates have increased, but patients are now subjected to longer and more intensive regimens. The impact of physical activity (PA) on health-related quality of life (HRQoL) in South African cancer patients and survivors with chemotherapy-induced peripheral neuropathy (CIPN) remains unclear. Aim: This study aimed to explore the relationship between self-reported exercise participation and HRQoL in cancer patients with CIPN, including those currently undergoing treatment and survivors. Setting: The study was conducted in oncology centres across Gauteng province, South Africa. Methods: Self-reported questionnaires (n = 305), including the Global Physical Activity Questionnaire (GPAQ) and the Functional Assessment of Cancer Therapy and/or Gynaecologic Oncology questionnaire (FACT/GOG-Ntx) were distributed in oncology centres and online. Results: Significant associations were found between HRQoL and PA. A negative correlation was observed between physical well-being and social (r = −0.289, p ≤ 0.000) and functional well-being (r = −0.447, p = 0.000). A positive correlation was found between physical and emotional well-being (r = 0.608, p = 0.000). Furthermore, significant correlations were identified between physical well-being and moderate-intensity exercise at work (r = −0.286, p = 0.046), exercise for leisure (r = −0.249, p = 0.009), and walking/cycling (r = −0.311, p = 0.013). Conclusion: Physical activity is associated with improved physical well-being in cancer patients and survivors with CIPN. Exercise may enhance HRQoL and alleviate CIPN symptoms.