Transcriptomic insights into the effects of monocrotophos on Chrysomya megacephala: forensic implications of altered pupation time

Molecular expression profiling showed 17,865 Differentially Expressed Genes, among which 8,731 were downregulated, and 9,134 were upregulated. Functional annotation (KOG) and pathway enrichment analysis (GO and KEGG) revealed that the effect of monocrotophos alters the expression of a significant number of genes involved in various biological processes, including amino acid, carbohydrate, and lipid transportation and metabolism; proteolysis; monooxygenase activity; regulatory RNA binding; regulation of gene expression; signal transduction; xenobiotics biodegradation and metabolism; and glycan biosynthesis and metabolism.