Molecular characterization of early-stage lung adenocarcinoma presenting as subsolid nodules in a real-life European cohort
Our study presents the molecular profile of subsolid lung adenocarcinoma in a real-life European-cohort. KRAS-mutations were the most prevalent, and were related to smoking history, higher CTR and faster growth. Conversely, common EGFR-mutations were rarer than expected and unrelated to smoking history and radiological features.
Authors
- Federico Cappuzzo (ORCID: https://orcid.org/0000-0002-6295-6767)
- Vincenzo Ambrogi (ORCID: https://orcid.org/0000-0002-8947-3175)
- Filippo Tommaso Gallina (ORCID: https://orcid.org/0000-0001-5579-0837)
- Simonetta Buglioni (ORCID: https://orcid.org/0000-0002-5066-1523)
- Daniele Forcella
- Antonello Vidiri
- Enrico Melis (ORCID: https://orcid.org/0009-0002-8076-7553)
- Fabiana Letizia Cecere (ORCID: https://orcid.org/0000-0002-6881-6773)
- Paolo Visca (ORCID: https://orcid.org/0000-0001-8484-6991)
- Francesca Fusco (ORCID: https://orcid.org/0000-0002-9768-5768)
- Alexandro Patirelis (ORCID: https://orcid.org/0009-0009-7409-8470)
- Riccardo Tajè (ORCID: https://orcid.org/0009-0008-3120-3886)
- Federico Cappelli
- Gabriele Alessandrini (ORCID: https://orcid.org/0000-0002-4380-7627)
- M Caterino
Institutions
- University of Rome Tor Vergata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12885-025-13998-0
- Citations
- 3
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Ministero della Salute
- National Cancer Institute