Effects of orally administration free and Liposomal Levamisole on hematological and biochemical parameters in Sheep

Analysis of haematological and biochemical parameters monitors animal health and guides diagnosis and treatment. This study compared the haematological and biochemical effects of free and liposomal levamisole given to sheep orally. The study included twenty-one female Curly breed sheep. The animals were divided into three groups: free levamisole (7.5 mg/kg), liposomal levamisole (7.5 mg/kg), and control (physiological serum 7.5 mL/kg). Blood samples were obtained on day (d) 0 (control), d 1, and d 3. Haematological parameters (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV, RDW-SD, and PCT) were assessed utilizing a haematology analyzer, while biochemical parameters (urea, creatinine, AST, ALT, BUN) were evaluated using an autoanalyzer. On d 1, the liposome group exhibited the highest white blood cell measurements. Despite a reduction in PCT values on d 1 within the liposome group, an increase was observed again on d 3. Urea levels on d 1 and 3 were elevated in the control, liposomal levamisole, and free levamisole groups. On d 3, creatinine measurements indicated that levels in the control group were significantly elevated compared to those in the liposomal levamisole and free levamisole groups. On d 3, BUN measurements indicated that the mean for the control group was significantly elevated compared to the liposomal levamisole and free levamisole groups. The Neutrophil, Lymphocyte, and Monocyte counts in the liposomal and free levamisole groups of animals were significantly elevated compared to other measurements recorded on the d 3. This study’s findings demonstrate that liposomes affect haematological and biochemical parameters. The results demonstrate that liposomal levamisole causes no harmful effects on animals. It produces advantageous results. Further investigation is necessary to elucidate the effects of Liposomal Levamisole on hematological and biochemical parameters among various animal species.