Laparotomy and burst suppression-inducing sevoflurane induce subtle long-term changes in anxiety and social behavior in late postnatal mice
Both surgery and excessive anesthesia depth are necessary to induce subtle yet long-term behavioral changes in young mice. Future preclinical studies should reconsider sevoflurane concentration and account for surgical trauma as a significant factor when investigating anesthesia-induced neurotoxicity.
Authors
- Jianchen Cui (ORCID: https://orcid.org/0000-0003-3200-6063)
- Jun Young Heo (ORCID: https://orcid.org/0000-0002-0859-0063)
- Yulim Lee
- Chul Hee Choi (ORCID: https://orcid.org/0000-0003-2373-048X)
- Woosuk Chung (ORCID: https://orcid.org/0000-0002-6409-2325)
- Boohwi Hong (ORCID: https://orcid.org/0000-0003-2468-9271)
- Xianshu Ju (ORCID: https://orcid.org/0000-0002-4339-5415)
- Ji Ho Park (ORCID: https://orcid.org/0000-0001-9722-8463)
- Y. D. Kim
- Tao Zhang (ORCID: https://orcid.org/0000-0003-1048-4443)
- Seongeun Kim (ORCID: https://orcid.org/0000-0002-4203-6816)
Institutions
- Kunming University of Science and Technology (CN)
- Seoul National University of Science and Technology (KR)
- Chungnam National University (KR)
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- The First Hospital of Kunming (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Sejong General Hospital (KR)
- Chungnam National University Hospital (KR)
Publication Details
- Journal
- Korean journal of anesthesiology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.4097/kja.24768
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Chungnam National University
- National Research Foundation of Korea
- Chungnam National University Hospital