Epidemiology of sepsis in hospitalised neonates in Indonesia: high burden of multidrug-resistant infections reveals poor coverage provided by recommended antibiotic regimens
Our multicentre study across three sites in Indonesia revealed neonatal sepsis is predominantly caused by Gram-negative pathogens, with very poor coverage provided by currently recommended empiric regimens. A high burden of multidrug-resistant pathogens drives empirical use of broad-spectrum antibiotics. There is an urgent need for new antibiotic regimens and infection prevention and control strategies to treat neonatal sepsis in regions with a high prevalence of multidrug-resistant infections.
Authors
- Dominicus Husada (ORCID: https://orcid.org/0000-0001-9191-9546)
- Tetty Yuniati (ORCID: https://orcid.org/0000-0002-6710-6665)
- Leny Kartina (ORCID: https://orcid.org/0000-0003-0610-0996)
- Fabiola Cathleen (ORCID: https://orcid.org/0000-0001-9591-6561)
- Mike Sharland (ORCID: https://orcid.org/0000-0001-8626-8291)
- Phoebe Williams (ORCID: https://orcid.org/0000-0003-2250-0594)
- Martono Tri Utomo (ORCID: https://orcid.org/0000-0003-4828-2134)
- Riyadi Adrizain (ORCID: https://orcid.org/0000-0001-6939-3306)
- Benjamin D. Dickson (ORCID: https://orcid.org/0000-0001-6860-903X)
- Nina Dwi Putri (ORCID: https://orcid.org/0000-0003-0153-9852)
- Jannah Baker (ORCID: https://orcid.org/0000-0002-2208-6584)
- Distiayu Sukarja
- M. Harrison (ORCID: https://orcid.org/0000-0003-2303-9883)
- Adhi K Suginali
Institutions
- The University of Sydney (AU)
- St George's, University of London (GB)
- Taronga Conservation Society Australia (AU)
- University of Indonesia (ID)
- UNSW Sydney (AU)
- Dr. Hasan Sadikin General Hospital (ID)
- Sydney Children's Hospital (AU)
- Universitas Dr. Soetomo (ID)
Publication Details
- Journal
- BMJ Global Health
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/bmjgh-2024-016272
- Citations
- 4
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Medical Research Council
- National Health and Medical Research Council