Longitudinal description of health-related quality of life and depressive symptoms in polyQ spinocerebellar ataxia patients
The trend direction of HRQoL and its significant association with the severity of ataxia symptoms align with the literature. The rapid worsening of self-care problems, the differential associations between depression and HRQoL sub-dimensions in different SCA subtypes, and the unexplainable resilience may warrant a deeper look at patient-specific intra- and interpersonal factors.
Authors
- Thomas Klockgether (ORCID: https://orcid.org/0000-0001-6174-5442)
- Marcus Grobe‐Einsler (ORCID: https://orcid.org/0000-0002-1808-2134)
- Jennifer Faber (ORCID: https://orcid.org/0000-0003-3265-0262)
- Maresa Buchholz (ORCID: https://orcid.org/0000-0002-4486-8632)
- Iris Blotenberg (ORCID: https://orcid.org/0000-0002-2273-5564)
- Heike Jacobi
- Tanja Schmitz‐Hübsch (ORCID: https://orcid.org/0000-0003-4833-5937)
- Bernhard Michalowsky (ORCID: https://orcid.org/0000-0002-3425-0089)
- Feng Xie (ORCID: https://orcid.org/0000-0003-3454-6266)
- Arif Iskandar
Institutions
- University of Bonn (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- Universitätsmedizin Greifswald (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Heidelberg (DE)
- The Centre for Health (New Zealand) (NZ)
- Hamilton Health Sciences (CA)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1007/s00415-025-13024-0
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91