Adjusting morphologies of wound dressing by transferring skin textures through electrospinning technology

Surface topography and mechanical properties of wound dressing significantly influence cell behavior and tissue regeneration process. Skin has unique textures, which are often overlooked in the preparation of wound dressings. Herein, we fabricated biomimetic wound dressings by transferring the surface textures of skin through electrospinning technology. Specifically, the top and bottom surface of pig skin employed as substrates for the collection of electrospinning nanofibers composed of polylactic acid and gelatin (PLLA/GL). Due to the existence of hair on the top surface of pig skin, the transferred nanofiber membrane (skin-top) exhibited scattered small pores (∼50 μm). In contrast, the transferred nanofiber membrane with aluminum foil (Al) as substrate displayed a smooth surface. Benefit from the unique surface properties of skin, the skin-based nanofiber membrane demonstrated improved roughness and enhanced air permeability. Specifically, skin-top based wound dressing showed the best performance in promoting wound healing, including enhanced epithelialization and collagen deposition. Illustration of the preparation of electrospinning nanofiber membrane with different substrates. • Biomimetic wound dressings with skin textures were prepared. • The top surface of pig skin facilitated the formation of scattered pores in the dressing. • Wound dressings with skin textures accelerated wound closure, and promoted angiogenesis.