Lumpy skin disease virus ORF142 protein inhibits type I interferon production by disrupting interactions of TBK1 and IRF3
These results suggest that LSDV ORF142 antagonizes host antiviral innate immunity by affecting the binding between TANK-binding kinase 1 and IRF3. Our findings provide new information regarding the pathogenesis of this virus.
Authors
- Kun Jia (ORCID: https://orcid.org/0000-0001-8586-4243)
- Jinping Chen (ORCID: https://orcid.org/0000-0002-0808-6617)
- J. Wang (ORCID: https://orcid.org/0009-0007-7209-2978)
- Shizhe Liu
- Chuanli Liu
- Heyu Li
- Baochun Lu
- Zihan Chen (ORCID: https://orcid.org/0009-0006-3412-0897)
- Qifeng Jiang
- Huijuan Zeng
Institutions
- South China Agricultural University (CN)
- Jilin University (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12917-025-04714-y
- Citations
- 5
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- China Agricultural University
- South China Agricultural University
- Guangzhou Municipal Science and Technology Project