Comparative study of pathomorphological changes in uterus and placenta during pregnancy with positive Omicron and Delta SARS‐CoV‐2 variants

In recent years, numerous studies have been conducted to examine the effects of COVID-19 on pregnancy; however, the pathomorphological changes in the uterus and placenta during this infection remain under-researched. This study aimed to evaluate pathomorphological changes in the uterus and placenta of pregnant women with positive COVID-19 results compared to a non-infected control group. A prospective analytical study including 48 pregnant women tested positive for COVID-19 (24 cases with Delta and 24 Omicron variants) and 42 pregnant women in the control group was conducted. Placental and uterine samples were analyzed using standard histological methods. Results indicated that pregnant women with COVID-19 showed a significant increase in the frequency of retroplacental hematomas, villous hypoplasia, vascular ectasia, and other histopathological changes in the uterus and placenta, especially in women tested positive for Delta variant. This study underscores that Delta SARS‐CoV‐2 variant is associated with marked pathological changes in the placenta and uterus, highlighting the need for careful clinical management in such pregnancies.