Effectiveness and Toxicity of High-Dose Colistin Treatment in Patients with Multidrug-Resistant Gram-Negative Bacterial Infections

High doses of colistin could be associated with a favorable clinical improvement in patients with MDRGN infections but has a limited effectiveness in extra-pulmonary infections, especially when a source-control procedure is not performed. AKI is frequently observed and limits its use, while eosinophilia and respiratory depression should be considered also as part of safety monitoring. Prescription of this drug should be judiciously analyzed weighing benefits-to-risk ratio.