Improvements induced by retinal gene therapy with voretigene neparvovec depend on visual cortical hemispheric dominance mechanisms
Our findings show a contribution of known early and high-level cortical dominance mechanisms on improvement, which constrain the effects of therapy and are therefore a target for neurorehabilitation. These findings provide insight into the limits of clinical benefits of gene therapy and suggest that neurorehabilitation approaches may be needed to enhance improvements, similarly to cochlear implants.
Authors
- Maria Beatriz Ferreira (ORCID: https://orcid.org/0000-0003-2911-7993)
- Hugo Quental (ORCID: https://orcid.org/0000-0001-9504-6543)
- João Pedro Marques (ORCID: https://orcid.org/0000-0002-1014-0483)
- Miguel Castelo‐Branco (ORCID: https://orcid.org/0000-0003-4364-6373)
- Miguel Raimundo
Institutions
- Hospitais da Universidade de Coimbra (PT)
- Maastricht University (NL)
- Escola Superior de Tecnologia da Saúde de Coimbra (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1038/s43856-025-00820-y
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia