AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p/FOXP1
AGE-induced release of macrophage-derived exosomes may partially depend on Rab27a transport, which delivers miR-22-5p to ECs. This miR-22-5p targets FOXP1 in ECs, leading to inflammation and resulting in endothelial dysfunction that accelerates the development of diabetic vascular lesions.
Authors
- Changnong Chen
- Lihua Pang
- Yang Cheng (ORCID: https://orcid.org/0000-0003-1702-7122)
- Yun Zhong (ORCID: https://orcid.org/0000-0003-3952-1260)
- Huanzhen Chen (ORCID: https://orcid.org/0009-0006-3713-1102)
- Yang Ji (ORCID: https://orcid.org/0000-0002-2226-7334)
- Lei Fang (ORCID: https://orcid.org/0000-0003-3999-7170)
- Jing Chen (ORCID: https://orcid.org/0009-0007-3004-7386)
- Shiming Liu (ORCID: https://orcid.org/0000-0003-1081-9741)
- Sha Wang (ORCID: https://orcid.org/0000-0002-1271-6052)
- Benrong Liu
Institutions
- Tung Wah Hospital (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Songshan Lake Materials Laboratory (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12933-025-02715-7
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China