Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations
We present a comprehensive characterization of causal variants, regulatory elements, and effector genes underlying AOA and COA genetics. Our results supported a distinct genetic basis between AOA and COA and highlighted regulatory complexity at many GWAS loci marked by both extensive pleiotropy and allelic heterogeneity.
Authors
- Nathan Schoettler (ORCID: https://orcid.org/0000-0001-9851-6352)
- Robert D. Mitchell
- Carole Ober (ORCID: https://orcid.org/0000-0003-4626-9809)
- Jing Gu (ORCID: https://orcid.org/0000-0001-5436-2339)
- Christine Billstrand
- Ivy Aneas
- Noboru J. Sakabe (ORCID: https://orcid.org/0000-0003-1817-6090)
- Xiaoyuan Zhong (ORCID: https://orcid.org/0000-0002-1948-6464)
- Emma E. Thompson (ORCID: https://orcid.org/0000-0002-9562-6414)
- Isabella M. Salamone (ORCID: https://orcid.org/0000-0002-0016-3091)
- Marcelo A. Nóbrega (ORCID: https://orcid.org/0000-0002-2134-9661)
- Anne I. Sperling (ORCID: https://orcid.org/0000-0002-4265-9212)
- Xin He (ORCID: https://orcid.org/0009-0005-6204-8557)
Institutions
- University of Chicago (US)
- University of Virginia (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s13073-025-01459-z
- Citations
- 8
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- National Human Genome Research Institute
- NIH Office of the Director
- National Institute of Allergy and Infectious Diseases