Identification of immune-related cervical cancer prognostic biomarkers and construction of prognostic model based on tumor microenvironment
Immune-related prognostic biomarkers in CC include HLA-DMA, DMBT1, CXCR6, CX3CL1, and SEMA3A. The risk score for the five genes is more accurate than that for other clinical risk factors in predicting prognosis at 3 and 5 years. The higher the risk score is, the worse the prognosis of CC patients is. Five prognostic biomarkers may participate in regulating TME through chemokine-mediated signaling pathways and receptor-ligand interactions. These findings provide new insights into the immunotherapy of CC.
Authors
- Wenlu Tang (ORCID: https://orcid.org/0000-0001-9448-578X)
- Qiufang Bao (ORCID: https://orcid.org/0009-0008-1944-7431)
- Wenzhong Tang (ORCID: https://orcid.org/0000-0001-8347-8592)
- Linliang Hong
- Xiaohong Zhu
- Bin Zhang (ORCID: https://orcid.org/0000-0002-9549-5653)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s40001-025-02515-5
- Citations
- 3
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.17
Funders
- Natural Science Foundation of Fujian Province