Assessment of a Polygenic Risk Score in Screening for Prostate Cancer
In a prostate cancer screening program involving participants in the top decile of risk as determined by a polygenic risk score, the percentage found to have clinically significant disease was higher than the percentage that would have been identified with the use of PSA or MRI. (Funded by the European Research Council Seventh Framework Program and others; BARCODE1 ClinicalTrials.gov number, NCT03857477.).
Authors
- Nafisa Hussain (ORCID: https://orcid.org/0009-0007-2715-0913)
- Elizabeth Bancroft (ORCID: https://orcid.org/0000-0002-5482-5660)
- Susan Merson
- Angela Wood (ORCID: https://orcid.org/0000-0002-7937-304X)
- Rosalind A. Eeles (ORCID: https://orcid.org/0000-0002-3698-6241)
- Samuel J. Withey (ORCID: https://orcid.org/0000-0002-3612-844X)
- Justyna M. Sobczak
- Bradley Russell
- Ann-Britt Jones
- Tokhir Dadaev (ORCID: https://orcid.org/0000-0002-8268-0438)
- Nicholas David James (ORCID: https://orcid.org/0000-0002-7314-8204)
- Jana McHugh
- Dean Y. Huang (ORCID: https://orcid.org/0000-0002-5637-6723)
- Reshma Rageevakumar
- Kathryn Myhill
- Syed Arshad Hussain (ORCID: https://orcid.org/0000-0002-3298-6260)
- Sarah Benafif (ORCID: https://orcid.org/0000-0003-1407-1697)
- Michelle Ferris (ORCID: https://orcid.org/0000-0002-7177-5490)
- Matthew Hogben (ORCID: https://orcid.org/0000-0003-3416-345X)
- Aslam Sohaib (ORCID: https://orcid.org/0000-0001-7774-9886)
- Fionnuala Croft
- Questa Karlsson
- Kaljit Kaur
- Zsofia Kote‐Jarai (ORCID: https://orcid.org/0000-0002-6329-5155)
- Mark N. Brook (ORCID: https://orcid.org/0000-0002-8969-2378)
- Naami Charlotte Mcaddy (ORCID: https://orcid.org/0000-0002-3185-2586)
- Edward Saunders (ORCID: https://orcid.org/0000-0001-6381-4018)
- Samantha Bennett (ORCID: https://orcid.org/0000-0003-2729-4734)
- Imran Rafi (ORCID: https://orcid.org/0000-0001-9673-9675)
- Netty Kinsella (ORCID: https://orcid.org/0000-0003-3807-9503)
- Barbara Benton
- Sarah Wakerell
- Eva McGrowder (ORCID: https://orcid.org/0009-0006-3988-9494)
- Sibel Saya (ORCID: https://orcid.org/0000-0002-4796-6852)
- Richard Nicholson
- Andrea Osborne
- Claire McNally
- Nening M. Dennis (ORCID: https://orcid.org/0000-0001-9488-3470)
- Dhruv Patel (ORCID: https://orcid.org/0009-0007-8876-3553)
- Alison Thwaites
- Nora Pashayan
- Stephen Hazell
- F. Mutch
- Elizabeth Page
- Denzil James
- Natalie Taylor
- Declan J. Cahill (ORCID: https://orcid.org/0000-0001-8618-0724)
- Pardeep Kumar (ORCID: https://orcid.org/0000-0002-9416-1723)
- Lenita Kingston
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- The University of Melbourne (AU)
- St George's, University of London (GB)
- King's College London (GB)
- University of Cambridge (GB)
- Institute of Cancer Research (CA)
- University College London (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1056/nejmoa2407934
- Citations
- 58
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 88.06
Funders
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Peacock Trust
- Royal Marsden Cancer Charity
- Cancer Research UK
- European Research Council