High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis
High matrix stiffness degrades lamin A/C in pulmonary fibrosis through lysosomal degradation pathways, promoting AEC II senescence. Inhibition the degradation of lamin A/C could alleviate AEC II senescence.
Authors
- Junhui Ba (ORCID: https://orcid.org/0000-0002-8537-2289)
- Benquan Wu (ORCID: https://orcid.org/0000-0002-1622-7993)
- Yanqiu Zhao (ORCID: https://orcid.org/0000-0001-6085-396X)
- Yimei Lai
- Xiaowu Deng (ORCID: https://orcid.org/0000-0003-2923-1251)
- Nan Wang (ORCID: https://orcid.org/0009-0006-1132-8054)
- Xin He (ORCID: https://orcid.org/0000-0002-7999-5981)
- Yan-Hong Pan (ORCID: https://orcid.org/0000-0002-7825-2334)
- Huihui Xie
- Changyu Zheng
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Genoimmune Medical Institute (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12931-025-03201-0
- Citations
- 6
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University