Analysis of Concurrent Intracholecystic Papillary Neoplasms and Biliary Intraepithelial Neoplasia Reveals Distinct Histologic and Molecular Profiles
BilIN in the background of ICPNs was of the same or lower grade than ICPNs. Synchronous ICPNs and BilIN lacked concordant somatic mutations. Mutations in adenocarcinomas aligned with the ICPNs. This suggests that ICPN and BilIN are independent at the DNA level and that the presence of ICPNs may not imply risk for subsequent flat dysplasia elsewhere in the biliary tree.
Authors
- Nicole C. Panarelli (ORCID: https://orcid.org/0000-0002-1121-267X)
- Preeti Malik (ORCID: https://orcid.org/0000-0002-9427-0225)
- D. Goldstein (ORCID: https://orcid.org/0000-0001-6367-8335)
- Kritika Krishnamurthy (ORCID: https://orcid.org/0000-0003-0772-0150)
- Faisal Sheikh (ORCID: https://orcid.org/0000-0003-2903-8953)
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- Cornell University (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Archives of Pathology & Laboratory Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.5858/arpa.2024-0340-oa
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00