Amyloid and Tau Pathology in Cognitively Unimpaired Individuals With a Parental History of Alzheimer Disease
Women and, surprisingly, individuals with a paternal history of AD seemed more vulnerable to the Aβ-related spread of tau, whereas women showed greater brain resilience to Aβ. Understanding sex-specific risk and resilience could allow more clinical trial precision and personalization. A major limitation included the reduced sample for the affected AD parent's sex analyses.
Authors
- Alfonso Fajardo-Valdez
- Judes Poirier
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- John C.S. Breitner (ORCID: https://orcid.org/0000-0003-4229-4687)
- Valentin Ourry (ORCID: https://orcid.org/0000-0002-8535-9009)
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Douglas Mental Health University Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1212/wnl.0000000000213507
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36