Heterogeneity of predictive biomarker expression in gastric and esophago-gastric junction carcinoma with peritoneal dissemination
G/EGJ with PM show distinct molecular features and spatial heterogeneity, with MMR, EBER, and HER2 demonstrating strong concordance, while PD-L1 showed greater variability. As for novel biomarkers, CLDN18.2 shows substantial concordance between primary G/EGJ and PM and could be a promising target in HER2/PD-L1-negative G/EGJ with PM.
Authors
- Federica Grillo (ORCID: https://orcid.org/0000-0001-6477-3182)
- Valentina Angerilli (ORCID: https://orcid.org/0000-0002-9799-9257)
- Alessandro Vanoli (ORCID: https://orcid.org/0000-0002-2976-7032)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Angelo Paolo Dei Tos (ORCID: https://orcid.org/0000-0002-1228-8940)
- Francesca Bergamo (ORCID: https://orcid.org/0000-0002-8795-4653)
- Michele Paudice (ORCID: https://orcid.org/0000-0003-4188-4247)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Claudio Luchini (ORCID: https://orcid.org/0000-0003-4901-4908)
- Paola Fugazzola (ORCID: https://orcid.org/0000-0002-6227-9276)
- Gaya Spolverato (ORCID: https://orcid.org/0000-0002-7275-2573)
- Luca Mastracci (ORCID: https://orcid.org/0000-0003-0193-5281)
- Giuseppe De Lisi
- Ilaria Govoni
- Matilde Callegarin
Institutions
- University of Padua (IT)
- Radboud University Nijmegen (NL)
- University of Pavia (IT)
- Casa Sollievo della Sofferenza (IT)
- Radboud University Medical Center (NL)
- AULSS 2 Marca Trevigiana (IT)
- Istituto Oncologico Veneto (IT)
- Radboud Institute for Molecular Life Sciences (NL)
- Ospedale Policlinico San Martino (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Gastric Cancer
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1007/s10120-025-01609-7
- Citations
- 9
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 13.67
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Padova