Performance of rapid diagnostic tests, microscopy, and qPCR for detection of Plasmodium parasites among community members with or without symptoms of malaria in villages located in North-western Tanzania
High prevalence of Plasmodium parasites was detected, and the performance of RDTs and qPCR was comparable, but microscopy had lower performance. Higher sensitivity of RDTs compared to microscopy indicates that RDTs are effective for detection of infections caused by Plasmodium parasites in routine case management and surveillance in this area with confirmed artemisinin partial resistance (ART-R) and can be utilized in the ongoing plans to develop a response to ART-R.
Authors
- Sijenunu Aaron (ORCID: https://orcid.org/0009-0008-0793-3782)
- Ntuli Kapologwe (ORCID: https://orcid.org/0000-0003-0900-2937)
- Filbert Francis (ORCID: https://orcid.org/0000-0003-1000-4729)
- Rashid A. Madebe
- Samwel Lazaro
- Abdallah Lusasi
- Misago D. Seth (ORCID: https://orcid.org/0000-0002-6743-4108)
- Ruth B. Mbwambo (ORCID: https://orcid.org/0000-0002-1089-1236)
- Daniel Mbwambo (ORCID: https://orcid.org/0009-0001-1089-2482)
- Dativa Pereus (ORCID: https://orcid.org/0000-0003-2813-1312)
- Daniel P. Challe (ORCID: https://orcid.org/0000-0002-6009-4649)
- Deus S. Ishengoma (ORCID: https://orcid.org/0000-0003-2040-3416)
- Rule Budodo (ORCID: https://orcid.org/0000-0003-0297-9219)
- Catherine Bakari (ORCID: https://orcid.org/0000-0002-8710-1765)
- Celine I. Mandara (ORCID: https://orcid.org/0000-0003-4317-4425)
- Stella Kajange
- Salehe S. Mandai (ORCID: https://orcid.org/0009-0001-8088-8761)
- Ramadhan Moshi
- Daniel A. Petro
- Angelina J. Kisambale (ORCID: https://orcid.org/0009-0002-6913-6558)
- Gervas A. Chacha
Institutions
- Muhimbili University of Health and Allied Sciences (TZ)
- University of Dar es Salaam (TZ)
- African Malaria Network Trust (TZ)
- Ministry of Health, Community Development, Gender, Elderly and Children (TZ)
- National Institute for Medical Research (TZ)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12936-025-05361-2
- Citations
- 7
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 13.15
Funders
- Bill and Melinda Gates Foundation
- Brown University
- Centers for Disease Control and Prevention Foundation
- Centers for Disease Control and Prevention
- University of North Carolina at Chapel Hill