Ketomimetic nutrients remodel the glycocalyx and trigger a metabolic defense in breast cancer cells
Our findings revealed that a ketomimetic medium enhances chemoresistance and invasive disposition of BC cells via two main oncogenic pathways: hypersialylation and lipid synthesis. We propose that the crosstalk between these pathways, juxtaposed at the synthesis of the glycan precursor UDP-GlcNAc, furthers advancement of a metastatic phenotype in BC cells under ketomimetic conditions. Non-cancerous cells lack this dual defense machinery and end up being sensitized to DOX under ketomimetic conditions.
Authors
- Hsin‐Chih Yeh (ORCID: https://orcid.org/0000-0003-4113-629X)
- Erin H. Seeley
- Amy Brock (ORCID: https://orcid.org/0000-0001-8255-9024)
- Yuan-I Chen
- Stephanie K. Seidlits (ORCID: https://orcid.org/0000-0003-3881-7166)
- Sapun H. Parekh (ORCID: https://orcid.org/0000-0001-8522-1854)
- Mohini Kamra (ORCID: https://orcid.org/0009-0004-2405-3120)
- Paula Delgado
Institutions
- The University of Texas at El Paso (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s40170-025-00385-3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Welch Foundation
- Cancer Prevention and Research Institute of Texas
- University of Texas at Austin
- National Institutes of Health