Enhancing Akkermansia growth via phytohormones: a strategy to modulate the gut-bone axis in postmenopausal osteoporosis therapy
SI and Nar may influence the gut-bone axis through Akkermansia and have the potential of alternative treatment options for postmenopausal osteoporosis. Although the gut microbiota is not significantly affected by the subcutaneous administration of Deno, the long-term management of postmenopausal osteoporosis and the exploration of various management models warrant additional scrutiny. Furthermore, this study has yet to establish a dose-response relationship, indicating that further research is essential to clarify the regulatory effects of varying doses of SI and Nar on postmenopausal osteoporosis especially the modulation of gut microbiota.
Authors
- Haibiao Sun
- Yixuan Deng
- Xin Wang (ORCID: https://orcid.org/0000-0002-4327-5720)
- Li Li (ORCID: https://orcid.org/0000-0002-8496-4573)
- Xiaoqiong Li (ORCID: https://orcid.org/0000-0002-2614-4219)
- Jinjun Li (ORCID: https://orcid.org/0000-0003-4662-7207)
- Xiaoqiang Han (ORCID: https://orcid.org/0000-0003-2647-6747)
- Lìyǐng Zhū (ORCID: https://orcid.org/0000-0002-5948-0227)
- Zhiqi Zhao (ORCID: https://orcid.org/0000-0002-1239-1948)
Institutions
- Hangzhou Normal University (CN)
- Shanxi Medical University (CN)
- Wenzhou Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1186/s12967-025-06426-1
- Citations
- 5
- Primary Topic
- Phytoestrogen effects and research
- Type
- article
- Field-Weighted Citation Impact
- 7.36