Trained immunity alleviates the progression of melanoma during sepsis-associated immunoparalysis
Sepsis can promote cancer progression by upregulating MIF and IL-6, increasing the G-MDSCs/M-MDSCs ratio and reducing the number and function of CD8<sup>+</sup> T cells, leading to immunoparalysis, while trained immunity can alleviate this progression. The findings of this study provide new strategies for preventing or treating sepsis-complicated cancer.
Authors
- Huan Dou (ORCID: https://orcid.org/0000-0001-6330-398X)
- Jingman Li
- Guangfeng Zhao (ORCID: https://orcid.org/0000-0002-9547-0798)
- Lijie Yin
- Jiali Wang (ORCID: https://orcid.org/0000-0001-8215-5417)
- Yayi Hou (ORCID: https://orcid.org/0000-0002-1152-9132)
- Yue Dong
- Renjie Luo
Institutions
- Nanjing University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1007/s13402-025-01063-8
- Citations
- 1
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Nanjing Medical Science and Technique Development Foundation