Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior
AP improves the potential therapeutic benefits of depression by targeting the PTGS2 signaling pathway, thereby promoting the wider use of AP in depression.
Authors
- Meng Yang (ORCID: https://orcid.org/0000-0002-1466-0769)
- Zhenhua Bian
- Deping Zhao (ORCID: https://orcid.org/0000-0001-5242-4233)
- Xia Lei (ORCID: https://orcid.org/0000-0002-2077-587X)
- Hongdan Xu (ORCID: https://orcid.org/0000-0002-7920-0069)
- Li Yang (ORCID: https://orcid.org/0000-0001-9098-694X)
- Ke Yuan (ORCID: https://orcid.org/0000-0001-5978-2148)
- Kun Zuo (ORCID: https://orcid.org/0000-0002-5503-6161)
- Xin Ma (ORCID: https://orcid.org/0000-0001-8209-3068)
- Ao X (ORCID: https://orcid.org/0000-0002-6522-5687)
- Ning Zhang (ORCID: https://orcid.org/0000-0003-0399-5085)
- Hongmei Zhao (ORCID: https://orcid.org/0000-0002-4520-0490)
- Shih-Tsung Cheng (ORCID: https://orcid.org/0000-0001-7005-4061)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiamusi University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Jingzhou Maternal and Child Health Hospital (CN)
- Wuxi No.2 People's Hospital (CN)
- Wuxi Vocational Institute of Commerce (CN)
- Wuxi Taihu Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1016/j.jep.2025.119792
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84